Unconventional T cells – New players in antifungal immunity

Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially immunocompromised patients and successful resolution of IFD requires a variety different immune cells. With the limited repertoire available antifungal drugs there is need for more effective therapeutic strategies. This review interrogates evidence on human response to main pathogens driving IFD, with focus role unconventional lymphocytes e.g. natural killer (NK) cells, gamma/delta (γδ) T mucosal associated invariant (MAIT) (iNKT) cells innate lymphoid (ILC). Recent discoveries new insights into roles these novel lymphocyte groups immunity will be discussed, we explore how an improved understanding action by can inform efforts improve treatment options.